THERAPEUTIC INDEX OF TRICYCLIC ANTIDEPRESSANTS

Tricyclic antidepressants have a narrow therapeutic index and can cause toxicity , even at therapeutic doses. The toxicity is related to their mechanism of .

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19 Aug 2008 . Tricyclic antidepressants (abbreviation TCA) are a class of . . Tricyclics have a narrow therapeutic index, i.e. the therapeutic dose is .

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Although selegiline is a selective MAO-B inhibitor at therapeutic . . by CYP2D6 and have a narrow therapeutic index, such as tricyclic antidepressants, .

2 Mar 2010 . Drugs such as flecainide, encainide, vinblastine, carbamazepine and tricyclic antidepressants which have a narrow therapeutic index should .

. doses (see therapeutic index) are farther apart than with the tricyclic . Tricyclic drug test card. Tricyclic Antidepressants drugs of abuse test .

Chemical structure of the tricyclic antidepressant amitriptyline .


Therapeutic Index Of Tricyclic Antidepressants Therapeutic Index Of Tricyclic Antidepressants

by A Ostapowicz - Cited by 1 - Related articles

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Lustral, an antidepressant drug similar to citalopram, fluoxetine, . . by 2D6 and which have a narrow therapeutic index, e.g., the tricyclic antidepressant .

by DL Loosbrock - 2002 - Cited by 16 - Related articles

23 Nov 2009 . Since the introduction of tricyclic antidepressants (TCAs .

Patients of all ages who are started on antidepressant therapy should be .

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Therapeutic Index · Cipla palliative care . . Monoamine Oxidase Inhibitors or Tricyclic Antidepressants Salbutamol should be administered with extreme .

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Therapeutic Index Of Tricyclic Antidepressants Therapeutic Index Of Tricyclic Antidepressants

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Antidepressant(selective serotonin reuptake inhibitor); . particularly medications having a narrow therapeutic index , such as tricyclic antidepressants .

Therefore, as with other antidepressants, fluoxetine should be introduced . tricyclic antidepressants and other selective serotonin antidepressants) involves the . and which have a narrow therapeutic index (such as flecainide, encainide, . . There was a therapeutic effect at 20mg/day, but higher doses (40 or .

1 May 2004 . Whether a polymorphism has relevance in therapeutic decision making . . higher blood levels of tricyclic antidepressants and faster therapeutic . some medications because of their narrow therapeutic index and how it .

The history of antidepressant pharmacotherapy begins with the tricyclic . . Acute Therapeutic Index. There are now multiple antidepressant options .

26 Oct 2009. and Ancillary Substances > By therapeutic use > Antidepressants > Drug Monographs . The Merck Index. Baclofen. The Merck Index > Monographs > B > BA . Baclofen and tricyclic antidepressants: possible interaction. .

Therapeutic Index · Cipla palliative care . . Monoamine Oxidase Inhibitors .

by SJ Gardiner - 2006 - Cited by 94 - Related articles

Zoloft® (sertraline HCl) is a type of antidepressant known as a selective . . and which have a narrow therapeutic index, e.g., the tricyclic antidepressant .

. benzodiazepines taken continuously at therapeutic levels for several months. . and the tricyclic antidepressants, and by other anticonvulsant drugs. .


Therapeutic Index Of Tricyclic Antidepressants Therapeutic Index Of Tricyclic Antidepressants

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. by CYP2D6 and have a narrow therapeutic index (e.g., flecainide .

by HL LEONARD - 1997 - Cited by 86 - Related articles

Tricyclic antidepressants may precipitate or aggravate psychotic . depends on the variability of effect on CYP2D6 and the therapeutic index of the TCA. .

3 Jan 2009 . Anyone considering the use of Zoloft or any other antidepressant in a . . a narrow therapeutic index, e.g., the tricyclic antidepressant .

by JU Rosholm - 1993 - Cited by 37 - Related articles

Families and caregivers of patients being treated with antidepressants for . .. which have a narrow therapeutic index, e.g., the tricyclic antidepressant .

by WM Asselin - Cited by 3 - Related articles

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Therapeutic Index Of Tricyclic Antidepressants Therapeutic Index Of Tricyclic Antidepressants

by W Steimer - 2001

16 Jan 2011 . Tricyclic antidepressants have a narrow therapeutic index and, therefore, become potent cardiovascular and central nervous system toxins in .

17 Jun 2010 . *TCA's, Tricyclic antidepressants. Prevent reuptake of NE and serotonin into presynaptic terminals. *Have a narrow therapeutic index. .

Thus, the dose of tricyclic antidepressant (TCA) may need to be reduced and . The aforementioned drugs with a narrow therapeutic index represent the .

5 Jan 2008 . Its use is being depreciated because of a lower therapeutic index than other sedative tricyclics with similar clinical efficacy. .

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7 Dec 2009 . Tricyclic antidepressants are one of the oldest classes of . . channels in contrast to TCAs, they all have a wide therapeutic index (ie, .

by R Eiber

Therapeutic Index - the ratio of largest non-toxic dose to smallest effective dose of . Tricyclic Antidepressant (TCA) - an older class of antidepressant .

15 May 2004 . Tricyclic antidepressants have a long and successful history in the . A full therapeutic response can be achieved after five to seven .

by M Peer

13 Apr 2005 . Tricyclic antidepressants: Amitriptyline, Clomipramine, Desipramine, . Digoxin - The low therapeutic index of digoxin means that dose .

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23 Dec 2009 . Drugs such as flecainide, encainide, vinblastine, carbamazepine and tricyclic antidepressants which have a narrow therapeutic index should .

Tricyclic antidepressant overdose is caused by excessive use or overdose of . due to the drugs narrow therapeutic index combined with it's cardiovascular .

Tricyclic antidepressants have a narrow therapeutic index: A lethal dose is only eight times the therapeutic dose. Between 25% and 50% of patients admitted .

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Tricyclic Antidepressants (TCA). Properties broadly divided between . Its use is complicated by its narrow therapeutic index (click here to view slide .

Although selegiline is a selective MAO-B inhibitor at therapeutic .

17 Dec 2008. of greatest concern are those metabolized primarily by .

1 Feb 2011 . Natural and Alternative Treatments Index Page . typical recommended dose, yohimbine has what is known as a "narrow therapeutic index. . Tricyclic antidepressants, bupropion, phenothiazines, clonidine, other drugs for .

Tricyclic antidepressants (TCAs) are heterocyclic chemical compounds used . . lethal overdose (see therapeutic index) are far wider in comparison. . .. " Tricyclic antidepressant pharmacology and therapeutic drug interactions updated" . .

. flecainide, thioridazine, tricyclic antidepressants): Use with caution, especially with drugs with a narrow therapeutic index. .

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Therapeutic Index Of Tricyclic Antidepressants Therapeutic Index Of Tricyclic Antidepressants

Suicidality and Antidepressant Drugs. Antidepressants increased the risk . . have a narrow therapeutic index, e.g., the tricyclic antidepressant drugs .

Patients taking drugs with a narrow therapeutic index such as tricyclic antidepressants should be discouraged from using herbal products. .

1) Define therapeutic drug monitoring and outline circumstances where it is useful. . the drug has a small therapeutic index, i.e., the concentration difference . . The tricyclic antidepressant drugs include imipramine and its .

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Drugs are all assessed a therapeutic index, which determines the quantitative . drugs with a known narrow therapeutic index: tricyclic antidepressants, .

13 posts - 8 authors - Last post: 11 Nov 2010the study above says that temazepam's fatal toxicity index (which is 11.9) is higher than many tricyclic antidepressants. . This is not true. while benzos are safe and have a high therapeutic index, they do cause .

Suicidality and Antidepressant Drugs. Antidepressants increased the risk compared . .. a narrow therapeutic index, e.g., the tricyclic antidepressant drugs .

Keltner (2002) commented on this by underlying the fact that the narrow therapeutic index of tricyclic antidepressants (TCAs) makes such interaction effects .

by SH PRESKORN - 2002 - Cited by 8 - Related articles

Index Terms. Nortriptyline Hydrochloride. Generic Available . . Iobenguane I 123: Tricyclic Antidepressants may diminish the therapeutic effect of .


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by S Preskorn - 1997 - Cited by 7 - Related articles

26 Aug 2008 . The first tricyclic antidepressant discovered was imipramine .

5 Jun 2010 . Tricyclic antidepressants as a class have a relatively narrow therapeutic index; there is a significant risk of toxicity with blood levels .

by SH Preskorn - 1994 - Cited by 88 - Related articles

15 Mar 2007 . However, drugs with a narrow therapeutic index, like tricyclic antidepressants and lithium, may be used as well. .

see our comprehensive coverage of Tricyclic antidepressant overdose. Tricyclic antidepressants have a narrow therapeutic index and therefore become potent .

Tertiaryamine tricyclic antidepressants (TATCAs) have a narrow acute therapeutic index due to their inhibition of sodium (Na+) fast channels at .

The tricyclic antidepressants have a high toxicity and low therapeutic index ( the difference between a recommended safe dose and lethal dose) that is as .